Fig. 1: Overview of the HLA gene alterations and HLA class I expression in ATL cells.
From: Full-length HLA sequencing in adult T cell leukemia–lymphoma uncovers multiple gene alterations
A Overview of the HLA gene alterations found in ATL patients. Nine patients had ATL cells showing a loss of HLA genes and/or non-silent variants (NSVs). Open rectangles indicate intact HLA alleles. Closed black and red rectangles indicate HLA alleles with genetic loss and NSVs, respectively. Closed gray rectangles indicate alleles with suspected but not confirmed genetic loss because of germline homozygosity at the loci. Six of the nine patients had HLA-LOH and/or NSVs in both alleles of the same HLA loci. For example, ATL08 showed loss of the HLA-A*02:06-C*03:03-B*35:01 haplotype and also showed NSVs in HLA-A*31:01 and HLA-B*56:01. ATL 20 had NSVs in both HLA-A alleles and in both HLA-C alleles. B MFI (mean fluorescence intensity) ratios in patients with HLA-LOH and/or NSVs and in those without HLA-LOH and/or NSVs. MFI ratio indicates the relative MFI ratio of ATL cells to non-ATL cells. MFI ratios of HLA class I were compared between patients with and without HLA-LOH/NSVs using the Mann–Whitney U test.
