Fig. 2: Geneplots for patients treated with JAKi organized by pattern of JAKi failure (x-axis) and mutation category (y-axis). | Leukemia

Fig. 2: Geneplots for patients treated with JAKi organized by pattern of JAKi failure (x-axis) and mutation category (y-axis).

From: Clinical and molecular correlates of JAK-inhibitor therapy failure in myelofibrosis: long-term data from a molecularly annotated cohort

Fig. 2

a Baseline mutations present prior to start of JAKi therapy, with no difference in number or genes mutated between pattern of failure groups. b Geneplot demonstrating n = 55 patients with paired mutation analysis arranged by pattern of failure (n = 49) or ongoing response to JAKi (n = 6). Emergent mutations were more frequently observed in patients with JAKi failure due to AP/BP (n = 7/10) than failure due to cytopenia (n = 1/10, P = 0.006).

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