Fig. 1: KDM4C is a specific dependency in JAK2-mutated cells.
From: Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms
A Scatter plot showing the in vitro depletion scores of genes in JAK2-mutated cells versus non-JAK2-mutated cell lines according to the DepMap Avana CRISPR-Cas9 (Q4/21) database. Data points represent the median value of each sgRNA set. Scores of genes with dependencies (indicated by dependency scores < −0.5) in JAK2-mutated cells but no dependency in non-JAK2-mutated cells (dependency score > −0.5) are highlighted in red. B Venn diagram showing the number of JAK2-specific in vitro hits and the number of JAK2-V617F specific target genes as determined by phospho-proteome analyses [10]. Overlapping genes with high expression in JAK2-mutated cell lines are indicated in red. C Expression and functional dependency of KDM4C in JAK2-mutated versus non-JAK2-mutated cell lines. D Dependency scores of all KDM-gene-family members in myeloid cancer cell lines. Dependencies (dependency score < −0.5) in JAK2-mutated cell lines are indicated in blue, total number of dependencies in black.
