Fig. 7: MiR-146a targets CD147 in ALK+ ALCL promoting increased energy metabolism.
From: CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL
NPM-ALK promotes CD147 expression by downregulation of miR-146a and overexpression of C/EBPβ through the STAT3 signaling pathway [33]. CD147 promotes tumor growth and invasion by enhancing aerobic glycolysis in ALK+ ALCL.
