Fig. 1: Epigenomic response to glucocorticoids. | Leukemia

Fig. 1: Epigenomic response to glucocorticoids.

From: Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia

Fig. 1: Epigenomic response to glucocorticoids.

A Number of GC-responsive changes to H3K27ac enrichment and accessible chromatin (ATAC-seq; ATAC) in 697 (blue) and Nalm6 (red) cells across all timepoints is provided. Enhanced and reduced GC-responsive changes in chromatin state are shown separately. B H3K27ac enrichment ranking of SEs in 697 (left) and Nalm6 (right) cells is shown at the left. GC-responsive SEs are shown in dark blue (697) and red (Nalm6), pre-established or baseline SEs are shown in light blue (697) and pink (Nalm6) and non-SEs are shown in gray. The intragenic ZBTB16 SE is marked. IGV browser tracks of 697 ATAC-seq and H3K27ac enrichment at the intragenic ZBTB16 SE is provided at the right. C Number of H3K27ac HiChIP promoter loops to DEGs (absolute fold change >2) in 697 and Nalm6 cells, and after 6 and 24 h of GC treatment is shown. Upregulated DEGs are shown in green and downregulated DEGs are shown in red. Number of HiChIP promoter loops involving HGRs (green or red) and not involving HGRs (light green and pink) are provided. The percentage of total DEGs at each timepoint with HiChIP loops is provided above each plot.

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