Fig. 2: GC-responsive repression of AP-1 transcription factors. | Leukemia

Fig. 2: GC-responsive repression of AP-1 transcription factors.

From: Epigenomic profiling of glucocorticoid responses identifies cis-regulatory disruptions impacting steroid resistance in childhood acute lymphoblastic leukemia

Fig. 2: GC-responsive repression of AP-1 transcription factors.

A TOBIAS TF footprint score differences (x-axis) and their significance (y-axis) between 0 and 24 h timepoints in 697 cell lines is shown. Significant AP-1 family TF footprints with stronger scores at 0 h are highlighted and denoted in red. Several outlier TFs with significantly stronger scores at 24 h are depicted in blue, including GR or NR3C1 which is also highlighted. B RNA-seq log2 fold change of AP-1 TFs that are significantly repressed following 6 and 24 h of GC treatment in 697 (left) and Nalm6 (right) cells. C IGV browser tracks of HiChIP loops between a distal HGR and FOS promoter in 697 cells.

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