Fig. 7: A simplified schema of the proposed model. | Leukemia

Fig. 7: A simplified schema of the proposed model.

From: Prion infection modulates hematopoietic stem/progenitor cell fate through cell-autonomous and non-autonomous mechanisms

Fig. 7: A simplified schema of the proposed model.

PrPC-positive HSCs, but not PrPC-negative ones, in ME7-infected middle-aged mice at 5 months post-injection undergo an apoptotic cell death through a cell autonomous manner. Both of PrPC-negative and positive HSCs in ME7-infected old-aged mice at 7 months post-injection exhibit senescence by the preferential aged BM microenvironment through a non-cell autonomous manner.

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