Fig. 5: Tissue distribution of siRNA-LNPs. | Leukemia

Fig. 5: Tissue distribution of siRNA-LNPs.

From: Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia

Fig. 5

a Schematic illustration of LNPs labelling via click reaction. b Schematic illustration of the biodistribution experiments in RG mice. c In vivo imaging of RG mice treated either with labelled LNPs (LNP/NIR) or control mice treated with free NIR dye in PBS. d Schematic illustration of biodistribution experiment in leukaemic RG mice transplanted with luciferase-expressing Kasumi-1 cells. In vivo imaging of leukaemic mice (e) and leukaemic mass (f) after treatment with LNP/NIR showing the co-localisation of the bioluminescence and the fluorescence.

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