Fig. 8: RUNX1/ETO transcriptome modulation following siRNA-LNPs treatment in vivo. | Leukemia

Fig. 8: RUNX1/ETO transcriptome modulation following siRNA-LNPs treatment in vivo.

From: Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia

Fig. 8

a–e RNA-seq analysis on harvested Kasumi-1 cells from the in vivo survival experiment. a Quantification of RUNX1/ETO expression following LNPs treatment. b Heatmap showing the expression level of the top significantly changed RUNX1/ETO-direct target genes upon siRNA-LNPs treatment. c Gene enrichment analysis indicating reduction of the haematopoetic stem cells signature and RUNX1/ETO targets and induction of proinflammatory response. d Top enriched biological processes following siRNA-LNP treatment in vivo, data were analysed by Funrich. e Network of NF-kB activation by TNF signalling. The red labelled circles represent genes found significantly changed upon siRNA-LNP treatment.

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