Table 1 Patient characteristics of the dx cohort (n = 50).

From: The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome

Patient no.

Patient age [months]

Treatment protocol

sex

Time to event (last follow-up) [months]

% blasts

EGR3 ΔCT Mean

IGHM ΔCT Mean

CD79A ΔCT Mean

BLK ΔCT Mean

PTPN6 ΔCT Mean

HOXA9ΔCT Mean

1

5.0

Interfant-06

F

(40.1)

49

8.1850

3.9578

2.6439

5.1517

3.8854

13.3592

2

6.0

/

F

/

82

11.2758

4.1454

2.2853

4.3700

2.1229

3.9204

3

2.0

Interfant-06

F

(23.6)

46

9.3618

4.8963

2.7340

4.4007

4.4306

12.9546

4

6.0

Interfant-06

M

(17.1)

90

11.1637

9.1284

7.8716

9.8465

10.1343

11.5783

5

10.0

/

M

/

90

8.8214

5.4178

6.2042

10.2556

9.6764

3.5974

6

2.0

Interfant-06

M

(83.6)

95

11.5618

6.2522

6.9626

8.1896

8.8812

4.9698

7

3.0

Interfant-06

F

(5.6)

96

8.5196

5.8631

2.8374

−1.4396

2.4810

11.0093

8

3.0

Interfant-06

F

(1.2)

71

8.2271

4.9521

5.1072

−0.4361

4.2495

4.9163

9

3.0

Interfant-06

M

(2.5)

85

8.0114

4.5490

3.3648

−0.8208

2.8412

4.5976

10

6.0

Interfant-06

F

9.5 (10.7)

98

12.3136

8.2192

8.1777

8.7455

8.1889

5.0818

11

0.1

/

F

/

96

11.2989

11.8824

9.8611

10.2911

9.2719

8.6964

12

1.0

/

M

/

98

11.6236

11.8944

8.6850

9.7199

9.8527

12.3443

13

12.0

/

F

/

90

9.1826

4.9885

1.9742

3.1891

−0.3517

2.2824

14

4.0

/

F

/

n/a

11.4695

6.3329

3.2521

4.4310

1.3435

11.4825

15

2.0

Interfant-06

M

6.0 (6.0)

90

13.3440

4.6279

2.6102

4.9218

1.1705

4.6973

16

5.5

Interfant-06

M

9.5 (15.0)

94

9.5330

9.9035

5.8136

6.3955

4.2272

6.2129

17

1.5

Interfant-06

F

10.0 (13.0)

92

6.2132

11.4431

8.3688

8.4548

6.1221

6.0703

18

3.0

Interfant-06

F

6.0 (11.5)

87

9.4723

9.2393

7.5200

8.7426

4.7647

2.0906

19

2.0

Interfant-06

F

10.5 (19)

96

7.2056

2.4819

2.0453

−1.9534

2.4821

7.8537

20

1.5

Interfant-06

M

26.5 (41.0)

96

11.2026

5.8739

4.8320

0.2568

6.2901

4.4627

21

6.5

Interfant-06

M

24.0 (32.8)

43

8.7817

6.5124

3.1900

0.3659

3.1614

11.2673

22

6.0

Interfant-06

F

19.5 (23.5)

94

10.0553

6.4983

2.9073

−1.3699

3.5784

11.5891

23

12.0

Interfant-06

F

32.0 (60.6)

92

8.0600

6.9642

4.0856

3.3604

1.6443

11.1226

24

9.0

Interfant-06

M

(84.9)

93

7.0569

3.3029

1.1508

2.1274

1.1842

8.7665

25

2.0

Interfant-06

F

(118.8)

93

10.2925

4.4468

1.7712

2.0883

0.4488

4.6017

26

3.0

Interfant-06

M

8.0 (108.5)

96

8.7375

7.0230

3.4687

4.0864

2.6431

13.0872

27

5.5

Interfant-06

M

(9.0)

95

9.1105

5.8320

2.9365

4.0461

1.5317

5.9626

28

5.0

Interfant-06

M

17.0 (33.0)

97

5.0456

5.0784

2.0327

4.8259

1.2226

5.9922

29

2.0

Interfant-06

F

56.0 (58.6)

90

9.3271

3.7605

3.9045

2.4719

4.2582

5.3297

30

1.5

Interfant-06

F

(146.1)

88

9.8910

3.3500

2.1610

0.6500

2.7175

5.8358

31

8.3

Interfant-06

F

(109.3)

81

6.5075

1.0567

0.0773

−0.7910

1.6433

2.2195

32

8.2

Interfant-06

M

(95.9)

92

7.2074

1.7896

2.8559

0.3826

0.8519

1.7726

33

10.7

Interfant-06

M

8.8 (8.8)

85

2.4138

-2.0719

0.3777

−0.1263

1.5011

2.6953

34

1.7

Interfant-06

F

(91.5)

93

6.2540

1.4646

1.9100

1.0432

2.1243

3.8579

35

11.7

Interfant-06

F

(73.2)

95

10.9273

4.7296

1.2813

3.3225

2.8393

2.9311

36

10.4

Interfant-06

F

(75.9)

92

10.4144

4.0039

2.3851

3.3520

2.9626

5.7541

37

2.4

Interfant-06

F

(73.8)

95

9.8438

5.2626

2.1926

4.1514

3.4033

13.3331

38

4.5

Interfant-06

M

16.1 (63.5)

87

11.4891

4.6039

1.4411

3.5708

2.5554

4.6562

39

1.1

Interfant-06

F

3.3 (15.7)

93

11.9464

6.0799

2.8532

4.2890

4.2377

12.9071

40

5.3

Interfant-06

M

(58.7)

94

10.3705

4.6305

2.2531

3.8496

3.0655

5.4284

41

6.9

Interfant-06

F

(63.2)

16

9.7053

5.4245

1.3355

3.4142

5.0462

9.2472

42

5.3

Interfant-06

M

(60.7)

88

9.5640

3.2046

−0.1283

2.8862

1.5220

3.4737

43

0.6

Interfant-06

F

5.0 (11.9)

97

8.6364

5.2214

1.5813

3.6253

2.8227

7.9122

44

1.5

Interfant-06

M

17.3 (18.3)

98

9.5745

6.0122

0.6954

3.0358

3.6119

8.1333

45

4.4

Interfant-06

M

6.6 (10.8)

82

10.2528

4.5355

0.2110

3.4874

2.4696

4.2993

46

9.1

Interfant-06

F

39.7 (45.2)

71

9.3985

5.1434

1.5751

4.8219

2.9164

3.1663

47

0.5

Interfant-06

F

8.7 (13.3)

93

9.9358

10.9029

7.9047

7.4532

8.7790

6.2701

48

6.1

AIEOP-BFM ALL 2017

F

6.6

n/a

9.4741

11.2982

8.5621

6.0722

10.3424

12.6734

49

6.1

AIEOP-BFM ALL 2017

F

8.3

n/a

10.5529

11.9934

8.9069

9.1727

8.9088

4.5847

50

10.6

/

M

/

n/a

5.1199

10.1187

9.3696

7.7286

11.0893

5.0774

  1. Samples were taken from PB at the day of diagnosis. Gene expression values are indicated as the ΔCT mean of technical triplicates.
  2. % blasts Blast percentages measured at diagnosis in PB, F female, M male.
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