Fig. 1: Project outline, PCA plots and volcano plots for pairwise differential expression comparisons. | Leukemia

Fig. 1: Project outline, PCA plots and volcano plots for pairwise differential expression comparisons.

From: Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

Fig. 1

A Consort diagram showing the order of investigation of the mRNA, miRNA and DNA methylation profiles of CLL. B (i) PCA plots using mRNA data and volcano plots for mRNA pairwise comparisons of (ii) U-CLL vs. M-CLL and (iii) M-CLL-S vs. M-CLL-NS. C (i) PCA plots using miRNA data and volcano plots for miRNA pairwise comparisons of (ii) U-CLL vs. M-CLL and (iii) M-CLL-S vs. M-CLL-NS. Points represent a mRNA or miRNA. Dark blue/red are differentially expressed at FDR ≤ 0.05 and log2FC ≥ ±1 after correcting for multiple testing (BH), light blue/pink are significant at P ≤ 0.05 and log2FC ≥ ±1.

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