Fig. 2: Identification of and expression of the 14q32 miRNA cluster in CLL. | Leukemia

Fig. 2: Identification of and expression of the 14q32 miRNA cluster in CLL.

From: Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

Fig. 2

A Over a third of the differentially expressed U-CLL vs M-CLL miRNAs were located in 14q32 miRNA clusters. Number in bar indicates number of DE miRNAs per chromosome. B (i) Mean miRNA expression of the 14q32 locus is lower in U-CLL than in M-CLL. (ii) The majority of the 14q32 miRNAs (purple points) were downregulated in U-CLL compared to M-CLL. C (i) Mean miRNA expression of the 14q32 locus is lower in M-CLL-S than in M-CLL-NS and shown to decrease from M-CLL-NS to M-CLL-S to U-CLL-S. (ii) The majority of the 14q32 miRNAs (purple points) were downregulated in M-CLL-S compared to M-CLL-NS. D Ribbon plot showing the expression of each miRNA in the 14q32 locus ordered by genomic loci from 5′–3′. Dark lines indicate the group median for each miRNA, connection between points is for clarity and no relationship between adjacent miRNAs is inferred. Coloured ribbons indicate the interquartile range for each group. miRNAs plotted include only those expressed at sufficient level to be reliably detected (see “Methods”).

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