Fig. 5: Expression of GAB1 and GAB1 targeting miRNA in CLL. | Leukemia

Fig. 5: Expression of GAB1 and GAB1 targeting miRNA in CLL.

From: Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

Fig. 5

A Boxplots of two miRNAs predicted to interact with GAB1 in silico divided by CLL group. P-values calculated using Wilcoxon signed rank test. B Boxplots of GAB1 mRNA and GAB1 protein expression for each CLL group. C Correlation of GAB1 protein with GAB1 mRNA, and correlation of GAB1 protein with mean 14q32 miRNA expression. Correlation statistics generated using Pearson’s correlation coefficient. D Representative GAB1 immunoblots for protein level assessment.

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