Table 4 Univariate and multivariate Cox proportional hazards models of post-transplantation outcomes for all NKTCL patients.

From: Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis

 

Overall Survival

Progression-free Survival

 

Univariate

Multivariate

Univariate

Multivariate

Variable

HR [95% CI]

P value

HR [95% CI]

P-value

HR [95% CI]

P value

HR [95% CI]

P value

Sex: female vs. male

1.15 (0.67–1.97)

0.61

  

1.03 (0.61–1.74)

0.92

  

Region: Europe vs. East Asia

0.84 (0.48–1.47)

0.55

  

0.85 (0.5–1.44)

0.55

  

Disease Stage: III/IV vs. I/II

1.04 (0.59–1.84)

0.89

  

1.06 (0.61–1.83)

0.84

  

PINK score at diagnosis: low/intermediate (0–1) vs. high (>1)

0.75 (0.37–1.54)

0.44

0.79 (0.36–1.76)

0.57

0.8 (0.4–1.57)

0.51

0.81 (0.39–1.70)

0.58

LDH at diagnosis: normal vs. elevated

0.58 (0.32–1.04)

0.07

  

0.74 (0.42–1.31)

0.3

  

Age at allo-HSCT: 0–40 vs. >40

0.97 (0.58–1.62)

0.91

  

1.03 (0.63–1.68)

0.91

  

Time to allo-HSCT: 0–12mo vs. >12mo

1.35 (0.81–2.26)

0.25

1.89 (0.88–4.02)

0.10

1.29 (0.79–2.1)

0.31

2.12 (1.03–4.34)

0.04

Status at allo-HSCT: non–CR vs. CR

1.27 (0.76–2.12)

0.36

  

1.17 (0.71–1.9)

0.54

  

Status at allo–HSCT: non–CR/PR vs. CR/PR

1.73 (0.97–3.07)

0.06

2.14 (0.92–4.98)

0.08

1.64 (0.94–2.86)

0.08

2.20 (0.98–4.95)

0.056

Number of prior treatments: >1 vs. 1

0.85 (0.46–1.58)

0.61

  

0.84 (0.46–1.52)

0.56

  

PD-1/PD-L1 treatment before HSCT: yes vs. no

0.8 (0.32–2.02)

0.64

  

0.83 (0.35–1.93)

0.66

  

Asparaginase before allo–HSCT: yes vs. no

1.57 (0.83–2.96)

0.16

1.96 (0.71–5.46)

0.20

1.91 (1.02–3.57)

0.04

2.52 (0.90–7.02)

0.08

Previous auto-HSCT: yes vs. no

0.52 (0.26–1.06)

0.07

  

0.64 (0.32–1.25)

0.19

  

Conditioning intensity: RIC vs. MAC

1.03 (0.62–1.71)

0.9

1.39 (0.66–2.91)

0.39

1.02 (0.63–1.66)

0.94

1.25 (0.62–2.53)

0.53

TBI as part of conditioning: yes vs. no

1.43 (0.84–2.45)

0.19

  

1.40 (0.83–2.35)

0.21

  

Donor type: Haploidentical vs. MRD/Unrelated

1.06 (0.57–1.97)

0.84

  

1.18 (0.66–2.1)

0.57

  

CR/PR1 vs. CR/PR2

0.68 (0.35–1.31)

0.25

  

0.7 (0.37–1.31)

0.27

  
  1. References for Cox proportional hazards are highlighted in bold.
  2. HR hazard ratio, CI confidence interval, PINK prognostic index for NK/T-cell lymphoma, LDH lactate dehydrogenase, CR complete response, PR partial response, RIC reduced-intensity conditioning, MAC myeloablative conditioning, MRD matched related donor, CR/PR1 first CR/PR, CR/PR2 second CR/PR, HSCT hematopoietic stem cell transplantation.
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