Fig. 7: Orthogonal validation of FGFR1 mediated regulation of MYC-EZH2-CDKN1C axis- in MCL. | Leukemia

Fig. 7: Orthogonal validation of FGFR1 mediated regulation of MYC-EZH2-CDKN1C axis- in MCL.

From: Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma

Fig. 7

A Western blots showing expression of p-Erk1/2, MYC, p-Rb, EZH2, KDM2B, and CDKN1C upon erdafitinib treatment of 3 MCL Patient-derived xenografts ex-vivo. B Tukey plots showing FGFR1, CDKN1C, TUBA1B, CDK1, UHRF1, and PCNA expression in 20 MCL patients compared to healthy donor B-cells. C Model showing the role of FGFR1 regulating feedback loop in MCL.

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