Table 1 KH16 and KH29 are more potent inducers of apoptosis than MS-275 and SAHA in FLT3-ITD-positive leukemic cells.

From: Histone deacetylase inhibitors modulate hormesis in leukemic cells with mutant FMS-like tyrosine kinase-3

 

KH16

KH29

MS-275

SAHA

hours

24

48

24

48

24

48

24

48

MV4-11 (IC50 nM)

52

46

57

62

814

706

658

629

MOLM-13 (IC50 nM)

41

37

63

85

621

628

533

586

  1. Shown are the IC50 values for apoptosis induction in MV4-11 and MOLM-13 cells that were treated with KH16, KH29, MS-275, or SAHA for 24-48 h. The values were calculated from the flow cytometry experiments (Fig. 1A–D) using GraphPad Prism 8.4.3; n = 3.
Back to article page