Fig. 4: Over-elongated centrioles in human plasma cells show additional structural abnormalities and are frequently fragmented.
A Exemplary visualizations of broken (top row), incomplete (bottom left), and asymmetric centriole phenotypes (bottom right). Phenotypes were additionally marked with arrow heads. Scale bar, 500 nm. B Violin plot and integrated box plots showing the length distribution of normal versus broken, asymmetric, and incomplete centrioles in CD138pos plasma cells from healthy donors and patients with plasma cell disorders. The cut-off value for over-elongation of 500 nm is displayed as red dashed line. C Distribution of centriole length depending on the number of appendages. The cut-off value for over-elongation of 500 nm is displayed as red dashed line. Appendages with equal distance from the distal end on the longitudinal axis of a mother centriole were subsumed as “Set of Appendages”.
