Table 1 Baseline characteristics of patients with plasma cell disorders.

From: High-throughput electron tomography identifies centriole over-elongation as an early event in plasma cell disorders

Description

MGUS

SMM

MM

PCL

N patients

4

3

12

2

Gender = female

1 (25.0)

0 (0.0)

1 (8.3)

1 (50.0)

Age, years

69.0 [62.0, 81.0]

57.0 [57.0, 64.0]

67.0 [57.0, 76.0]

63.5 [58.0, 69.0]

Prior lines of therapy

0.0 [0.0, 0.0]

0.0 [0.0, 0.0]

4.5 [0.0, 8.0]

6.5 [6.0, 7.0]

HDM + ASCT

0 (0.0)

0 (0.0)

10 (83.3)

2 (100.0)

BM plasmocytosis, %

8.4 [7.1, 9.1]

18.7 [11.5, 21.3]

58.7 [27.5, 91.0]

73.2 [50.0, 96.4]

Ki67+ PC, %

22.1 [16.0, 40.5]

27.3 [24.1, 39.4]

37.3 [6.4, 93.3]

78.9a

Salmon–Durie stage, I-II-III

  

0 (0.0) - 1 (8.3) - 10 (82.3)

 

Type of HC

    

 A

0 (0.0)

0 (0.0)

1 (8.3)

0 (0.0)

 G

2 (50.0)

2 (66.7)

8 (66.7)

1 (50.0)

 None

2 (50.0)

1 (33.3)

3 (25.0)

1 (50.0)

Type of LC = lambda

2 (50.0)

1 (33.3)

3 (25.0)

1 (50.0)

Monoclonal component, g/l

3.1 [3.1, 3.1]

6.0 [2.1, 10.0]

16.5 [3.8, 39.9]

4.2 [4.2, 4.2]

  1. Categorical data is shown as count (% of respective total), continuous data is shown as median [range]. BM plasmocytosis, fraction of plasma cells in bone marrow leukocytes.
  2. HC heavy chain measured in serum, LC light chain measured in serum, HDM+ASCT high-dose chemotherapy with melphalan followed by autologous stem cell transplantation.
  3. aThis parameter was only available for one patient with PCL.