Fig. 2: Co-existence of Srsf2P95H/+ and Asxl1Y588XTg mutation alters the function of HSC/HPCs.
From: SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis
A Flow cytometric analysis of HSC/HPCs in BM cells from representative mice of each genotype and quantification of the percentages of LSK and LKS- cells. B Flow cytometric analysis of LSK cells in BM cells from representative mice of each genotype and quantification of the percentage of LT-HSC and ST-HSC. C Flow cytometric analysis of myeloid cells in BM cells from representative mice of each genotype and quantification of the percentage of Gr1+/Mac1+ cells. D Representative MPO staining of spleen sections is shown. Scale bar, 50 μm. E The overlap of DEGs of Asxl1Y588XTg, Srsf2P95H/+ and Asxl1Y588XTg;Srsf2P95H/+ mice. F GSVA score distribution of representative pathways among all four genotypes (scaled among all 16 samples). *P < 0.05; **P < 0.01; ***P < 0.001.
