Fig. 2: Mutation pattern in tumors derived from DLBCL patients with poor outcomes following R-CHOP treatment. | Leukemia

Fig. 2: Mutation pattern in tumors derived from DLBCL patients with poor outcomes following R-CHOP treatment.

From: Genetic and transcriptomic analyses of diffuse large B-cell lymphoma patients with poor outcomes within two years of diagnosis

Fig. 2: Mutation pattern in tumors derived from DLBCL patients with poor outcomes following R-CHOP treatment.

A Catalog of the most frequently mutated genes in DLBCL tumors among patients with poor outcomes. Genes that affected by nonsilent mutations across more than three cohorts and observed in more than 8% of all patients (n = 702) were included. B Comparison of mutation frequencies between DLBCLs with poor and good outcomes using Fisher’s exact test, adjusted by the false discovery rate (FDR) q value (q < 0.1 was considered significant). The presented genes included those most significantly mutated between the two outcome groups and those with mutation frequencies greater than 10%. Genes with FDR q < 0.1 were indicated as red color. C Forest plots display the association between the mutation of individual/combined genes and PFS in the combined cohorts. D Donut chart illustrating the distribution of LymphGen DNA subtypes in patients with poor or good outcomes in the combined cohorts. Fisher’s exact test was used to compute p values. *p < 0.05; NA not available, UN unknown, HR hazard ratio, CI confidence interval, UNC unclassified.

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