Table 2 Mean AEA Ctrough after the first four doses of PEG-asparaginase in the different groups.
AEA Ctrough IU/L | |||||||
|---|---|---|---|---|---|---|---|
No inactivation | Inactivation | ||||||
IV | IM | IM and IV | IV | IM | |||
Dose | AEA (samples, n) Patients = 184 | AEA (samples, n) Patients = 24 | AEA (samples, n) Patients = 45 | AEA (samples, n) Patients = 42 | AEA (samples, n) Patients = 2 | AEA (samples, n) Patients = 1 | |
<16 years | ≥16 years | 1 < 16 years ≥23 | <16 years | ≥16 years | <16 years | ||
1 | 322 IU/L (156) | 168 IU/L (18) | 142 IU/L (22) | 295 IU/L (43) | 301 IU/L (40) | 70 IU/L (2) | 487 IU/L (1) |
2 | 413 IU/L (142) | 189 IU/L (13) | 199 IU/L (17) | 193 IU/L (38) | 203 IU/L (36) | 0 IU/L (1) | 0 IU/L (1) |
3 | 440 IU/L (130) | 270 IU/L (15) | 210 IU/L (11) | 94 IU/L (26) | 94 IU/L (26) | – | |
4 | 523 IU/L (73) | 197 IU/L (6) | 164 IU/L (8) | 0 IU/L (10) | 0 IU/L (9) | 0 IU/L (1) | |
