Table 1 Proposed changes in the interpretation section of the previous examples.
Example of the IGHV report | Interpretation |
|---|---|
IGHV-unmutated | Following the 98% germline identity cut-off which is used for discriminating CLL cases into the IGHV-mutated or IGHV-unmutated category, this case belongs to the IGHV-unmutated category which is generally associated with adverse prognosis and poor response to chemoimmunotherapy and a shorter progression-free survival when treated with fixed-duration treatments that include venetoclax plus an anti-CD20 antibody compared to IGHV-mutated cases [7]. |
Subset #2 | Following the 98% germline identity cut-off which is used for discriminating CLL cases into the IGHV-mutated or IGHV-unmutated category, this case belongs to the IGHV-mutated category. However, this particular rearrangement belongs to stereotyped subset #2 which is associated with adverse prognosis and poor response to chemoimmunotherapy regardless of the somatic hypermutation status [8, 9]. The predictive value of subset #2 for patients treated with targeted therapies is currently unknown. |
