Fig. 7: Model of MGA deficiency.
From: Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia
A Model of MGA deficiency in hematopoietic cells. The expression of full-length MGA leads to ncPRC1.6 complex formation and the deposition of repressive H3K27me3 of MYC target genes leading to a condensed and transcriptionally repressed chromatin status (top). Somatic mutations of MGA as seen in AML; lead to the abolishment of ncPRC1.6 complex formation leading to an open and transcriptionally active chromatin status.
