Table 1 Clinical characteristics.

From: Axicabtagene ciloleucel treatment is more effective in primary mediastinal large B-cell lymphomas than in diffuse large B-cell lymphomas: the Italian CART-SIE study

 

PMBCL (N = 70)

Other LBCL (N = 190)

p value

Sex

  

0.0312

  Female

34 (49%)

64 (34%)

 

  Male

36 (51%)

126 (66%)

 

Age

  

0.0001

  Mean (SD)

35.0 (11.4)

55.9 (12.3)

 

  Median [Q1, Q3]

33.0 [27.0, 41.8]

57.5 [50.0, 65.0]

 

Disease status

  

0.0048

  Refractory

63 (90.0%)

141 (74%)

 

  Relapse

6 (9%)

46 (22%)

 

  Missing

1 (1%)

3 (2%)

 

Ann Arbor

  

0.0001

  I–II

43 (61%)

64 (34%)

 

  III–IV

27 (39%)

126 (66%)

 

LDH

  

0.0958

  Mean (SD)

255 (243)

344 (574)

 

  Median [Q1, Q3]

190 [154, 264]

203 [167, 314]

 

  Missing

4 (6%)

8 (4%)

 

IPI

  

0.0078

  <3

55 (79%)

113 (59%)

 

  ≥3

15 (21%)

74 (39%)

 

  Missing

0

3 (2%)

 

Bulky disease

  

0.0015

  No

29 (42%)

122 (64%)

 

  Yes

40 (57%)

66 (35%)

 

  Missing

1 (1%)

2 (1%)

 

Number of previous treatments

  

0.3055

  Mean (SD)

2.60 (0.858)

2.49 (0.832)

 

  Median [Q1, Q3]

2 [2, 3]

2 [2, 3]

 

  Missing

0

3 (2%)

 

Previous ASCT

  

0.0778

  No

58 (83%)

136 (72%)

 

  Yes

12 (17%)

54 (28%)

 
  1. PMBCL primary mediastinal B-cell lymphoma, other LBCL large B-cell lymphoma other than primary mediastinal B-cell lymphoma, SD standard deviation, Q1 interquartile 1, Q3 interquartile 3, LDH lactate dehydrogenase, IPI international prognostic index, ASCT autologous stem cell transplantation.