Fig. 2: Overview of cross-talks between AML blasts and innate immune cells in the TME.
From: Targeting the innate immune system in pediatric and adult AML
A AML blasts polarize macrophages toward an M2-like phenotype (through arginase II secretion and via CSF1R). AML blasts escape phagocytosis by macrophages through the expression of CD47. B AML blasts secrete extracellular vesicles (EVs), containing the protein MUC1, leading to MDSCs expansion. C AML blasts inhibit NK cell cytotoxicity by activating immune checkpoints and secreting several factors, such as TGFβ, IL-10, IDO1, sNKG2D and microvesicles containing TGFβ, IL-10.
