Fig. 2: Copy number and clonal size evolution of gain/amp(1q) and its relationship with CIN phenotype in MM.

A The proportion of cells with gain/amp(1q) is indicated by the height of the bar on the y-axis. The proportion of cells with three, four, or ≥five copies of 1q21 in each sample is indicated by green, blue, and red, respectively. A total of 513 NDMM with gain/amp(1q) are ordered from the lowest to the highest proportion of cells with gain/amp(1q) from right to left on the x-axis. B Volin plot of the cell fraction of gain/amp(1q) in patients detected with different copy numbers of 1q. NS, not significant, *P < 0.05, **P < 0.01, by two-sided unpaired Student’s t tests. C Bar plot comparing the proportions of distribution of patients detected with different copy numbers of 1q according to the clonal size of gain/amp(1q). NS, not significant, ***P < 0.001, by 2-sided χ² test. D Frequency bar plot showing the number of CAs other than gain/amp(1q) detected by FISH among NDMM patients without gain/amp(1q) or with different clonal sizes of gain/amp(1q). E Comparison of proportion of high-risk CAs among patients without gain/amp(1q) or with different clonal sizes of gain/amp(1q). F Percentage frequency of genetic changes associated with minor, subclonal, and clonal gain/amp(1q). G Scatter plots demonstrate the relationship of gain/amp(1q) clonal fraction and del(13q) clonal fraction for patients with concomitant gain/amp(1q) and del(13q). H Scatter plots demonstrate the relationship of gain/amp(1q) clonal fraction and del(1p) clonal fraction for patients with concomitant gain/amp(1q) and del(1p).