Fig. 1: DDR genes as biomarkers predicting survival of AML patients.
From: DNA damage response genes as biomarkers of therapeutic outcomes in acute myeloid leukemia patients
A Consensus clustering of AML subjects in the BEAT AML 2.0 dataset into 5 groups with varying DDR transcriptomic signatures. B Kaplan-Meier plot showing the survival of the 5 groups. C Top 10 DDR biomarker genes with the highest expression in each cluster. D Kaplan-Meier plots of the difference in survival between subjects with high versus low scaled and normalized values of the DDR biomarker genes for clusters 1 and 5. High versus low cut points were determined via Thiele and Hirschfield’s method to find an optimal outcome-based cut point, survival. E The combined values of AIM2 and CDC42BPA are a powerful biomarker for survival in BEAT AML 2.0 and TARGET-recurrent AML databases.
