Fig. 7: Analysis of resistance mechanisms to mono-targeting. | Leukemia

Fig. 7: Analysis of resistance mechanisms to mono-targeting.

From: Rational combinatorial targeting by adapter CAR-T-cells (AdCAR-T) prevents antigen escape in acute myeloid leukemia

Fig. 7

A Representative flow cytometry analyses of bone marrow from relapsed mice. Expression of CD33, CD38 and CD371 on viable AML blasts for the indicated groups plotted as histograms. B UMAP, representing batched viable AML blasts in bone marrow from tumor-only mice, AdCAR-T-only mice and mice treated with AdCAR-T plus LLE-aCD33, LLE-aCD38, or LLE-aCD123 (n = 3 each condition), based on the expression of CD33, CD38 and CD123, as determined by flow cytometry. From left to right, expression of CD33, CD38, and CD371 color-coded, spatial localization of treatment naïve PDX cells ( = tumor only) and pseudotrajectories enforced by mono-targeting.

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