Fig. 5: Gata2R396Q/+ hematopoietic progenitors upregulate Gata2.
From: Modeling GATA2 deficiency in mice: the R396Q mutation disrupts normal hematopoiesis
FeaturePlots displaying the expression of Ctsg A ly6c1 B and Tgfbr3 C in WT and Gata2R396Q/+ LSK cells. D FeaturePlot displaying the expression of Gata2 in WT and Gata2R396Q/+ LSK cells. E Quantification and comparison of Gata2 expression for the indicated clusters in WT and Gata2R396Q/+ cells. F FeaturePlots displaying the expression of Gata2, Dntt, Ctsg, and Procr among Lymp Prog cells in WT and Gata2R396Q/+ samples. Dotted circle indicates a unique population found among the Gata2R396Q/+ Lymp Prog cluster. ns not significant, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. HSC hematopoietic stem cell, Lymp lymphoid, Prog progenitor, Int intermediate.
