Fig. 8: Gata2R396Q/+ disrupts normal hematopoiesis.
From: Modeling GATA2 deficiency in mice: the R396Q mutation disrupts normal hematopoiesis
During HSC generation at around embryonic day 10 (E10), Gata2R396Q/+ mice produce fewer definitive HSCs in the aorta gonad mesonephros (AGM). HSCs show reduced functional potential in the fetal liver at E12.5-E14.5, as well as intrinsic biases toward particular HSPC populations. During adulthood, the continued effects of dysregulated HSC generation manifest as reduced HSC function, biases toward LT-HSC and MPP2 production at the expense of ST-HSC production (driven by enhanced CD150 expression), myeloid bias, and suggestions of stem cell exhaustion/aging.
