Table 6 Recommendations for allo-HSCT recipients: post-engraftment.
Antifungal agent | Steroid treated acute GVHD | ECIL 5-6 |
|---|---|---|
Posaconazole tablet 300 mg q24h following a loading dose of 300 mg q12h on day 1, or oral solution 200 mg q8h | A-I a, b | A-I a, b |
Itraconazole 2.5-7.5 mg/kg q24h i.v. or 200 mg q24h p.o | B-I b | B-I b |
Voriconazole 6 mg/kg q12h first day then 4 mg/kg q12h i.v. or p.o. | B-I b | B-I b |
Micafungin 50 mg q24h | C-II | C-II |
Caspofungin and anidulafungin | no data | no data |
Liposomal amphotericin B | C-II | C-II |
Aerosolized liposomal amphotericin B (10 mg twice weekly) in combination with systemic fluconazole 400 mg q24h | no data | no data |
Fluconazole 400 mg q24h | D-III | D-III |
Isavuconazole 200 mg q24h following a loading dose of 200 mg q8h on days 1 and 2 c | B-II | no data |
