Fig. 3: Multivariate analysis of clinical signs and symptoms to evaluate the impact on thrombotic risk in the overall patient cohort.

CVRFs cardiovascular risk factors, HU hydroxyurea, HR hazard ratio, CI confidence interval. Red dots identify variable statistically significantly associated with a higher probability of thrombosis during hydroxyurea in both multivariate and univariate analysis; Yellow dots identify variable statistically significantly associated with a higher probability of thrombosis during hydroxyurea only in univariate analysis.