Fig. 3: IKAROS is essential for HDAC1 recruitment to the gene promoters. | Leukemia

Fig. 3: IKAROS is essential for HDAC1 recruitment to the gene promoters.

From: Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia

Fig. 3

A Heatmaps of HDAC1 ChIP-seq signals in IK-null T-ALL and day 1 following IKAROS re-expression. B HDAC1-only and HDAC1-IKAROS occupied sites classified by function of the DNA element. C Examples of IKAROS recruitment of HDAC1 to the promoters of IKAROS target genes. D Analysis of the differentially expressed genes directly regulated by IKAROS-HDAC1 complexes. E, F Gene ontology and pathway enrichment analysis of genes associated with IKAROS-HDAC1 complexes.

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