Fig. 4: Critical roles of IKAROS and Histone Deacetylase 1(HDAC1) in the global de novo formation of H3K27me3. | Leukemia

Fig. 4: Critical roles of IKAROS and Histone Deacetylase 1(HDAC1) in the global de novo formation of H3K27me3.

From: Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia

Fig. 4

A, B IKAROS, HDAC1, and Enhancer of Zeste homologue 2(EZH2) occupancy associated with H3K27me3 formation Day 1 (A) and Day 2 (B) following Ikzf1 re-expression. C EZH2 target genes are regulated by the IKAROS and HDAC1-induced epigenetic switch. EZH2 DNA occupancy at target genes does not induce H3K27me3 in Ikzf1-null T-ALL (top). A large number (75%) of EZH2-target genes undergo epigenetic switch with de novo H3K27me3 formation following Ikzf1-re-expression (middle). Most of the EZH2 target genes that undergo epigenetic switch are regulated by IKAROS and HDAC1 binding (bottom).

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