Table 3 Impact of donor type on event-free and overall survival in specific head-to-head comparisons defined by sex and CMV status constellations of donor and patient.

From: Young unrelated donors confer a survival advantage for patients with myeloid malignancies compared to older siblings

Sex & CMV constellation

Event-free survival

Overall survival

Rating of Unrelated Donor

Matched Unrelated* (N)

Matched Sibling (N)

HR (95% CI)

p

HR (95% CI)

p

Advantageous

Favorable (1538)

Unfavorable (649)

0.84 (0.73–0.96)

0.010

0.77 (0.67–0.90)

0.001

Neutral

Favorable (1538)

Favorable (570)

0.79 (0.68–0.91)

0.001

0.75 (0.64–0.87)

<0.001

Unfavorable (600)

Unfavorable (649)

1.01 (0.86–1.19)

0.92

1.01 (0.85–1.20)

0.95

Disadvantageous

Unfavorable (600)

Favorable (570)

0.93 (0.79–1.10)

0.38

0.96 (0.81–1.15)

0.68

  1. Favorable and unfavorable sex- and cytomegalovirus (CMV) serostatus-constellations of donor and patient were defined as follows: favorable was defined as concordant CMV status of donor and patient AND no female donor for a male patient; unfavorable was defined by a discordant CMV status OR a female donor for a male patient. Numbers (N) of transplantations available for the comparisons are given in brackets. HLA-compatible unrelated donors were matched for HLA-A, -B, -C, -DRB1, and DQB1. The hazard ratios for the donor type comparisons (reference category: HLA-identical sibling donor) are taken from multivariable Cox regression models adjusted for patient age, performance status, disease risk, conditioning intensity and stem cell source.
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