Table 1 Results of the integrative analysis between DNA methylation and gene expression data in Erdheim–Chester disease.
Chr | Gene | CpG | Integration | Methylation | Gene Expression | |||
|---|---|---|---|---|---|---|---|---|
R | P (FDR) | Δβ | P (FDR) | logFC | P (FDR) | |||
chr16 | ACSF3 | cg04879696 | –0,34 | 2,28E–02 | –0,01 | 5,94E–05 | 1,52 | 4,76E–07 |
chr19 | CLEC11A | cg10773601 | –0,38 | 1,90E–03 | –0,05 | 6,64E–03 | 2,34 | 6,73E–03 |
cg20308817 | –0,33 | 4,27E–02 | –0,04 | 6,13E–04 | ||||
chr17 | DNAH17 | cg07125124 | 0,39 | 1,38E–03 | 0,01 | 1,51E–04 | 4,67 | 6,55E–08 |
cg16403016 | –0,41 | 2,33E–04 | –0,03 | 2,52E–03 | ||||
cg27174444 | 0,35 | 1,62E–02 | 0,04 | 1,42E–07 | ||||
chr9 | EEF1A1P5 | cg17246894 | –0,35 | 1,80E–02 | 0,03 | 1,17E–09 | –2,84 | 5,72E–06 |
cg19777542 | 0,34 | 2,96E–02 | –0,01 | 8,80E–05 | ||||
chr1 | EIF1AXP1 | cg16109817 | –0,36 | 8,02E–03 | 0,01 | 5,39E–11 | –3,65 | 3,64E–05 |
chr16 | EIF3CL | cg27416312 | –0,33 | 4,88E–02 | –0,01 | 5,58E–03 | 2,78 | 1,92E–05 |
chr12 | EIF4B | cg01657380 | –0,34 | 2,44E–02 | 0,01 | 3,75E–03 | –1,00 | 7,84E–05 |
chr20 | FRG1BP | cg04692312 | 0,50 | 6,83E–08 | –0,15 | 8,17E–09 | –2,26 | 1,35E–04 |
cg09798387 | 0,41 | 3,70E–04 | –0,05 | 1,09E–03 | ||||
cg14709901 | 0,36 | 9,01E–03 | –0,02 | 6,18E–03 | ||||
cg15069499 | –0,46 | 3,66E–06 | 0,09 | 6,23E–12 | ||||
cg19196320 | –0,50 | 8,43E–08 | 0,09 | 2,98E–05 | ||||
chr5 | HK3 | cg05017829 | –0,33 | 3,63E–02 | –0,01 | 5,93E–04 | 1,56 | 1,23E–03 |
chr6 | HLA-J | cg20380424 | –0,42 | 1,02E–04 | 0,05 | 6,75E–04 | –5,25 | 1,99E–05 |
cg20408505 | 0,38 | 3,05E–03 | –0,06 | 9,61E–06 | ||||
chr6 | HLA-K | cg15411272 | 0,34 | 2,42E–02 | –0,19 | 8,06E–10 | –4,89 | 3,65E–05 |
chr9 | LINC00963 | cg13523245 | 0,45 | 9,05E–06 | 0,03 | 1,71E–04 | 1,43 | 5,16E–04 |
cg14854366 | –0,41 | 3,07E–04 | –0,04 | 1,09E–03 | ||||
cg21226933 | 0,43 | 7,87E–05 | 0,02 | 1,91E–04 | ||||
chr9 | LINC02908 | cg19993487 | –0,34 | 2,46E–02 | –0,02 | 2,29E–03 | 1,69 | 3,16E–03 |
chr8 | LRRC14 | cg12574437 | 0,35 | 1,27E–02 | 0,02 | 1,86E–03 | 1,38 | 1,02E–04 |
chr1 | LYSMD1 | cg01281797 | –0,44 | 3,71E–05 | –0,02 | 2,49E–04 | 1,73 | 1,41E–05 |
chr6 | MIR6891 | cg08509237 | –0,34 | 2,83E–02 | 0,01 | 6,78E–03 | –1,57 | 7,69E–04 |
chr8 | NAPRT | cg22097396 | –0,36 | 9,37E–03 | –0,04 | 3,59E–11 | 2,32 | 9,64E–05 |
cg25786937 | –0,37 | 6,23E–03 | –0,04 | 1,05E–04 | ||||
chr9 | NPDC1 | cg26581729 | –0,35 | 1,33E–02 | –0,03 | 6,13E–04 | 2,53 | 6,54E–05 |
chr11 | PRR33 | cg17501754 | 0,34 | 2,13E–02 | 0,01 | 4,64E–03 | 9,57 | 1,01E–12 |
chr19 | PWWP3A | cg14007004 | 0,36 | 7,83E–03 | 0,04 | 5,10E–03 | 0,99 | 1,33E–04 |
chr4 | RAC1P2 | cg09100767 | 0,36 | 8,02E–03 | –0,02 | 5,28E–04 | -4,11 | 7,16E–11 |
chr6 | RNASET2 | cg01075399 | –0,39 | 1,01E–03 | –0,03 | 4,08E–03 | 1,53 | 3,99E–04 |
cg20406979 | –0,54 | 1,41E–09 | –0,05 | 1,50E–05 | ||||
cg20486651 | –0,36 | 9,51E–03 | –0,07 | 1,13E–04 | ||||
cg24398081 | 0,35 | 1,82E–02 | 0,01 | 2,91E–03 | ||||
cg26887226 | 0,36 | 9,04E–03 | 0,03 | 2,37E–03 | ||||
chr5 | SLC22A5 | cg24887267 | –0,34 | 2,04E–02 | –0,01 | 2,13E–03 | 1,24 | 1,64E–04 |
chr14 | SLC25A29 | cg14064024 | –0,57 | 2,26E–11 | –0,05 | 2,72E–06 | 2,00 | 5,60E–04 |
chr3 | STIMATE-MUSTN1 | cg10525161 | 0,35 | 1,44E–02 | 0,01 | 5,99E–03 | 6,50 | 2,49E–12 |
chr10 | STK32C | cg01807317 | –0,36 | 9,47E–03 | –0,05 | 1,28E–05 | 1,49 | 6,11E–05 |
chr16 | TBC1D10B | cg16410688 | 0,33 | 4,68E–02 | 0,01 | 3,73E–04 | 1,23 | 5,60E–05 |
chr19 | TGFB1 | cg05217755 | 0,33 | 4,06E–02 | 0,01 | 1,99E–09 | 1,41 | 2,44E–05 |
chr22 | TRIOBP | cg16774942 | 0,33 | 3,45E–02 | 0,00 | 3,30E–18 | 1,28 | 4,42E–04 |
cg18442977 | 0,34 | 2,16E–02 | 0,00 | 5,57E–03 | ||||
