Table 2 Summary of the most relevant drugs identified in the drug repurposing analysis.
Associated gene | Target | Drug | Type | Current indication |
|---|---|---|---|---|
NAPRT | PNP | Cladribine | Small Molecule | Chronic lymphocytic leukemia, Cutaneous T-cell lymphoma, Non-Hodgkin’s lymphoma, Relapsing multiple sclerosis, Hairy cell leukemia |
LRRC14 | CHUK, IKBKB | Sulfasalazine | Small Molecule | Rheumatoid arthritis, Crohn’s disease, Ulcerative colitis, Proctitis, Polyarticular juvenile rheumatoid arthritis |
LRRC14 | IKBKB | Auranofin | Small Molecule | Rheumatoid arthritis |
LRRC14, TGFB1 | IKBKB, TGFBR1, TGFBR2 | Fostamatinib | Small Molecule | Chronic immune thrombocytopenia |
