Table 2 Differentially expressed genes between tCLL and oCLL with known relevant roles in CLL.

Gene symbol	Expression rank			Log₂ fold change			p-adjusted
Gene symbol	tCLL	oCLL	B cells	tCLL vs. oCLL	tCLL vs. B cells	oCLL vs. B cells	tCLL vs. oCLL	tCLL vs. B cells	oCLL vs. B cells
BCL2L11	0.78	0.88	0.93	–0.63	–1.28	–0.33	0.006	0.003	0.257
BCL3	0.92	0.82	0.91	0.92	–0.02	–0.87	<0.001	0.961	0.002
BTK	0.91	0.88	0.94	0.31	–0.50	–0.83	0.001	0.002	<0.001
CD79B	0.86	0.77	0.87	0.67	–0.05	–0.60	0.002	0.925	0.075
CD274 (PD-L1)	0.06	0.23	0.12	–1.72	–0.54	0.27	<0.001	0.203	0.278
LAG3	0.96	0.87	0.71	1.37	6.32	4.65	0.001	<0.001	<0.001
LYN	0.97	0.98	0.99	–0.32	–0.90	–0.55	0.001	<0.001	0.001
TIGIT	0.37	0.59	0.17	–1.80	2.48	4.40	<0.001	<0.001	<0.001

Comparison with normal mature B cells is also shown. tCLL: CLL harboring t(14;19); oCLL: other CLL cases, without t(14;19); Expression rank: gene ranking as expression level percentile in tCLL, oCLL, and B cells: 0 = lowest expression, 1 = highest expression.

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