Fig. 1: CAR-T treatment changes the endogenous T cell landscape. | Leukemia

Fig. 1: CAR-T treatment changes the endogenous T cell landscape.

From: The endogenous T cell landscape is reshaped by CAR-T cell therapy and predicts treatment response in multiple myeloma

Fig. 1

A Schematic overview of workflow. B UMAP of CD8 + T cells and CAR-T cells colored by clusters. C UMAP plots highlighting cells from each timepoint or CAR-T cells. D Expression of marker genes in different clusters. E Heatmap displaying expression of published gene signatures. F Comparison of proportion of cell states in endogenous T cells and CAR-T cells at M2D1 for patients. p = 0.11 for cluster 0, p = 0.36 for cluster 2, *p = 0.014 for cluster 6, p = 0.85 for cluster 1, p = 0.98 for cluster 3, p = 0.35 for cluster 4 and ***p = 2e-04 for cluster 5, respectively, by Wilcoxon test. G Volcano plot comparing endogenous CD8 + T cells at M2D1 vs. CAR-T cells. H Scoring of indicated signatures in endogenous CD8 + T cells at M2D1 vs. CAR-T cells. p < 2.2e − 16, p < 2.2e − 16, p = 4.7e − 06, p = 0.00031 by Wilcoxon test, respectively.

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