Fig. 1: Aggressive B-cell lymphoma cell lines are sensitive to MCL-1 inhibition.
From: Synthetic lethality of MCL-1 inhibition and CAR-T therapy in aggressive B-cell lymphoma
A Bar plot showing the log10-transformed 50% inhibitory concentrations (IC50) of B-cell lymphoma cell lines treated with S63845 for 72 h. B Correlation analysis between MYC protein expression levels and Log-transformed S63845 IC50 values. IC50 values were derived from MTT assay, and protein levels were determined by western blotting. Band intensities were quantified and normalized to HBL-2 as the reference cell line. C Western blot analysis of cleaved PARP (c-PARP) in lymphoma cell lines treated with the indicated concentrations of S63845 for 24 h indicating apoptosis induction. Data in (A) are representative of at least three independent experiments.
