Fig. 6: Single-Cell RNA-seq reveals tumor-intrinsic and microenvironmental remodeling following MCL-1 inhibition in MYC-associated B-cell lymphoma. | Leukemia

Fig. 6: Single-Cell RNA-seq reveals tumor-intrinsic and microenvironmental remodeling following MCL-1 inhibition in MYC-associated B-cell lymphoma.

From: Synthetic lethality of MCL-1 inhibition and CAR-T therapy in aggressive B-cell lymphoma

Fig. 6

A scRNA-seq analysis of control (V1 and V2) and MCL-1i-treated tumors (M1 and M2) from Eμ-MYC B cell lymphoma murine model and UMAP projection colored by graph-based cell clusters (upper panel) and experimental groups (lower panel). V: vehicle control, M: S63845 treatment. B Enrichment analysis by Enrichr for top ten enriched pathways of DEGs in MCL-1i-treated tumors (upper) and the control-treated tumors (lower). C The average percentages of tumor-infiltrating immune populations identified in A are shown for each group based on scRNA-seq analysis.

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