Fig. 2: Numerical evaluation of the performance of in-silico clearing RI tomography using a simulated multicellular spheroid.

a Maximum intensity projection (MIP) and cross-sections of RI distributions of ground truth, reconstructed without and with in-silico clearing, respectively. The cross-sections are identified with a white dashed line in MIP. b NRE, PSNR, and SSIM for without and with in-silico clearing as a function of depth. These metrics are computed in a layer-wise manner, where the layer thickness is set as lattice constant 18λ0