Fig. 6: In vivo anti-tumor and lung metastasis effect of photocatalytic HS-Pt-CDs for EMT6 breast tumor.
From: J-type assembled Pt(IV)-coordinated carbon dots for near-infrared light-triggered pyroptosis
a NIR photocatalytic therapy schedule. b Primary and (c) distant tumor growth curves for BALB/c mice by intravenous injection with one time Pt coordinated drugs treatment (at an equivalent Pt dose of 3.0 mg kg−1): G6: HS-Pt-CDs + 690 nm; G5: Pt-CDs + 690 nm; G4: HS-Pt-CDs; G3: Pt-CDs; G2: cisplatin; and G1: saline. d Representative immunohistochemical (IHC) images of tumors following a single treatment cycle. Scale bar: 50 μm. e Quantitative analysis of CD8+, CD4+ T cells and CD11c+ DCs in primary tumors (G1p, G2p, G3p, G4p, G5p, G6p) and distant tumors (G5d, G6d) from EMT-6 tumor-bearing mice. f Survival curves of the mice following various treatments. g Counting of metastatic lung nodules in mice following various treatments. h Digital images of lungs stained by H&E and fixed with Bouin’s liquid. The blue triangles denote metastatic nodules. i Representative immunohistochemical (IHC) images in lung sections of mice treated with saline, cisplatin, Pt-CDs + 690 nm, and HS-Pt-CDs + 690 nm. j Quantitative analysis of CD8+, CD4+ T cells and CD11c+ DCs in lungs. Data presented as mean ± S.D. p-values are calculated using two-tailed Student’s t-test and two-way ANOVA test, **p < 0.01, ****p < 0.0001)
