Fig. 3: Single‐shot volumetric optoacoustic reconstructions of the human palm vasculature, acquired without any spatial or temporal averaging.

a Compounded volumetric rendering of deep vessels (depth range 0–4 mm) in top view. b Close‐up view. c Side view. d Volumetric renderings of the superficial vascular plexus (depth range 100–200 µm) revealing multiple sweat pores (sp). Top view maximum intensity projection is shown. e Close-up view. f Representative OA signal line profiles measured across both small superficial capillaries and larger deep-seated vessels. g Multispectral volumetric rendering of relative oxygenation ratio (HbO/HbR) within the venules. Repeated volumetric optoacoustic acquisitions of blood oxygenation patterns (Supplementary Video 2) can be used to estimate slow venous blood flow velocities on the order of a few millimeters per second. All scale bars are 5 mm. Functional and real‐time angiographic performance of the array can be viewed in Supplementary Videos 1–2