Fig. 5: Comparisons of skin microvasculature endothelial function between volunteers with and without CVD.

a, b Cross-sectional RSOM images of a healthy volunteer (a) and a CVD volunteer (b). c, d The image intensity profiles were used to characterize endothelial function during the PORH test on a non-CVD healthy volunteer and a CVD volunteer. e–g Comparisons of the MVC (maximum volume change), HR (hyperemia ratio), and TP (time-to-peak) values, computed from the fRSOM image intensity profiles, between the healthy volunteers (HV) and CVD volunteers. Values were calculated from readings taken in the microvasculature of the subpapillary dermis (SD) layer, the reticular dermis (RD) layer, and the whole dermis vasculature (DV). h Comparison of the total blood volume in the dermal layer between the healthy volunteers and CVD volunteers. ns not significant. Scale bar: 500 µm