Fig. 3 | Modern Pathology

Fig. 3

From: Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles

Fig. 3

Genetic characterization of adenoid cystic carcinoma of the salivary gland, lacrimal gland, and breast. a Fluorescent in situ hybridization using break-apart probes for MYB and b NFIB showing separate red (arrows) and green (arrowheads) signals, indicating rearrangement in a breast adenoid cystic carcinoma. c The fusion probe demonstrates the presence of the MYB–NFIB fusion in the same specimen. d Break-apart probe demonstrating MYBL1 rearrangement that was identified exclusively in a subset of salivary gland carcinomas. e In a subset of non-rearranged cases, numerous green signals were found which is consistent with amplification of the 5′ part of the MYB gene. f In the non-rearranged carcinomas, all cases overexpressed MYB protein. g Overview of the genetic spectrum in salivary gland, lacrimal gland, and breast adenoid cystic carcinoma. MYB and NFIB involvement was seen in adenoid cystic carcinoma of all three organs, while MYBL1 was exclusively found in the salivary gland

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