Fig. 5 | Modern Pathology

Fig. 5

From: Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles

Fig. 5

MicroRNA expression profiling separates most breast from salivary gland adenoid cystic carcinoma irrespective of phenotypic profile and genetic status. Unsupervised hierarchical clustering of adenoid cystic carcinoma of the salivary gland, lacrimal gland, and breast clustered the majority of salivary gland carcinomas (51/64) and breast carcinomas (8/11) at each end of the spectrum. All lacrimal gland cases (9/9) clustered between the pure salivary gland and breast clusters. The lacrimal gland cluster included the remaining subset of salivary gland (11/64) and breast carcinomas (3/11). Clustering of cases occurred irrespective of architectural grade (solid), phenotypic profile, and gene status

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