Table 2 Rearrangements, fusions, and copy-number status of the MYB, NFIB, and MYBL1 genes in adenoid cystic carcinoma of the salivary gland, lacrimal gland, and breast

From: Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles

Split probe

Fusion probe

Amplification

Wild type

n

MYB

NFIB

MYBL1

MYB–NFIB

MYB

 

Salivary gland adenoid cystic carcinoma

 63

39

49

13

37

3

7

Lacrimal gland adenoid cystic carcinoma

 9

5

5

0

5

1

3

Breast adenoid cystic carcinoma

 11

4

6

0

4

0

4

  1. Summary of fluorescent in situ hybridization in adenoid cystic carcinoma using break apart and fusion probes. MYB and NFIB demonstrated split signals in the majority of cases, and the majority of these had fused MYB–NFIB signals. MYBL1 split signals were exclusively found in salivary gland carcinomas. Amplification of MYB was a rare event. Only a minority of cases were wild type
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