Table 2 Comparison of low vs. high counts of infiltrating immune cells in OSCC patientsa with and without HEVs using Fisher’s exact test

From: Presence of high-endothelial venules correlates with a favorable immune microenvironment in oral squamous cell carcinoma

 

All tumors

T1/T2

T3/T4

HEV+

HEV−

 

All HEV+

All (HEV+/−)

 

HEV+

 

HEV−

 

No. (%)

No. (%)

P

No. (%)

No. (%)

P

No. (%)

P

No. (%)

P

CD3

  Low

15 (22.4)

6 (85.7)

0.002

11 (21.2)

10 (47.6)

0.026

4 (28.6)

0.396

6 (85.7)

0.002

  High

52 (77.6)

1 (14.3)

 

41 (78.8)

11 (52.4)

 

10 (71.4)

 

1 (14.3)

 

CD4

  Low

44 (65.7)

5 (100.0)

0.170

34 (65.4)

14 (73.7)

0.359

9 (64.3)

0.587

5 (100.0)

0.138

  High

23 (34.3)

0 (0.0)

 

18 (34.6)

5 (26.3)

 

5 (35.7)

 

0 (0.0)

 

CD8

  Low

35 (52.2)

5 (100.0)

0.061

28 (53.8)

12 (63.2)

0.336

7 (50.0)

0.517

5 (100.0)

0.057

  High

32 (47.8)

0 (0.0)

 

24 (46.2)

7 (36.8)

 

7 (50.0)

 

0 (0.0)

 

CD20

  Low

26 (38.2)

6 (85.7)

0.038

20 (37.7)

12 (57.1)

0.104

6 (42.9)

0.478

6 (85.7)

0.022

  High

42 (61.8)

1 (14.3)

 

33 (62.3)

9 (42.9)

 

8 (57.1)

 

1 (14.3)

 

CD68

  Low

33 (48.5)

6 (85.7)

0.109

22 (41.5)

17 (81.0)

0.002

11 (78.6)

0.014

6 (85.7)

0.034

  High

35 (51.5)

1 (14.3)

 

31 (58.5)

4 (19.0)

 

3 (21.4)

 

1 (14.3)

 

DC-lamp

  Low

32 (51.6)

5 (71.4)

0.279

25 (53.2)

11 (52.4)

0.579

6 (42.9)

0.354

5 (71.4)

0.314

  High

30 (48.4)

2 (28.6)

 

22 (46.8)

10 (47.6)

 

8 (57.1)

 

2 (28.6)

 

Eosinophils

  Low

37 (55.2)

6 (85.7)

0.227

26 (50.0)

16 (76.2)

0.035

10 (71.4)

0.129

6 (85.7)

0.082

  High

30 (44.8)

1 (14.3)

 

26 (50.0)

5 (23.8)

 

4 (28.6)

 

1 (14.3)

 

Mast cells

  Low

32 (47.8)

6 (85.7)

0.108

25 (48.1)

13 (61.9)

0.209

7 (50.0)

0.568

6 (85.7)

0.068

  High

35 (52.2)

1 (14.3)

 

27 (51.9)

8 (38.1)

 

7 (50.0)

 

1 (14.3)

 

PD-L1

  Low

23 (59.0)

4 (66.7)

0.544

15 (50.0)

12 (85.7)

0.024

8 (100.0)

0.010

4 (66.7)

0.386

  High

16 (41.0)

2 (33.3)

 

15 (50.0)

2 (14.3)

 

0 (0.0)

 

2 (33.3)

 
  1. HEV high-endothelial venule
  2. aAnalyses for CD3+ cells, eosinophils, and mast cells were carried out in 74 patients, for CD4+ and CD8+ cells in 72 patients, for DC-lamp+ cells in 69 patients, and for PD-L1+ cells in 45 patients. All other analyses included 75 patients
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