Table 1 Basic clinicopathological characteristics of the Lynch and sporadic tumors investigated

From: Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance

 

Endometrial carcinoma

Ovarian clear cell carcinoma

Ovarian endometrioid carcinoma

Lynch

  Number of mutation carriers

34

8

13

  Number of samples

35c

9

14g

 Gradea

   G1

18 (55%)d

N/A

6 (46%)h

   G2

12 (36%)d

N/A

6 (46%)h

   G3

3 (9%)d

N/A

1 (8%)h

 Stageb

   I

25 (71%)

5 (56%)

7 (50%)

   II

4 (11%)

2 (22%)

4 (29%)

   III

4 (11%)

1 (11%)

3 (21%)

   IV

0 (0%)

0 (0%)

0 (0%)

   N/A

2 (6%)

1 (11%)f

 

 Average age at diagnosis (years)

49.3

45.8

47.6

Sporadic

  Number of samples

36e

39

28

 Gradea

   G1

15 (42%)

N/A

11 (39%)

   G2

5 (14%)

N/A

10 (36%)

   G3

16 (44%)

N/A

7 (25%)

 Stageb

   I

22 (61%)

21 (55%)

12 (43%)

   II

4 (11%)

2 (5%)

2 (7%)

   III

10 (28%)

14 (37%)

14 (50%)

   IV

0 (0%)

2 (5%)

0 (0%)

 Average age at diagnosis (years)

65.3

57.1

59.7

  1. N/A  not applicable
  2. aAccording to WHO (clear cell carcinomas are not graded)
  3. bAccording to FIGO
  4. cIncludes 31 endometrioid (used for molecular studies), two clear cell and two cervical adenocarcinomas
  5. dGrade frequencies are calculated per 33 tumors (clear cell tumors are not graded)
  6. eAll are of endometrioid histology
  7. fMetastatic carcinoma of the other ovary
  8. gOne of the tumors is borderline tumor
  9. hGrade frequencies are calculated per 13 tumors (borderline tumor is not graded)